Sympathomimetic Class
Adrenaline
Brand: EpiPen / Adrenaline Injection 1:1000
Subclass: Alpha & Beta adrenergic agonist
PK:
t½ 0.033 hours | Clearance: mixed
severe
AE: Palpitations, tachycardia, hypertension, anxiety, tremor, arrhythmias
AE: Palpitations, tachycardia, hypertension, anxiety, tremor, arrhythmias
Ephedrine
Brand: Ephedrine Sulfate (global)
Subclass: Alpha + Beta agonist; indirect NE releaser
PK:
t½ 6 hours | Clearance: renal
Max Dose: 150 day
Max Dose: 150 day
moderate
AE: Tachycardia, insomnia, anxiety, hypertension
AE: Tachycardia, insomnia, anxiety, hypertension
Isoprenaline
Brand: Isuprel
Subclass: Non-selective β-agonist
PK:
t½ 0.05 hours | Clearance: hepatic
severe
AE: Tachycardia, palpitations, arrhythmias, flushing, tremor, headache, hypotension
AE: Tachycardia, palpitations, arrhythmias, flushing, tremor, headache, hypotension
Midodrine
Brand: ProAmatine / Gutron
Subclass: Alpha-1 selective agonist
PK:
t½ 0.5 hours | Clearance: renal
Max Dose: 30 day
Max Dose: 30 day
moderate
AE: Supine hypertension, piloerection, pruritus, urinary retention
AE: Supine hypertension, piloerection, pruritus, urinary retention