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Antidepressant Class

Amitriptyline

Brand: Elavil (US/EU) / Tryptomer (IN) / Amitone (BD)
Subclass: TCA (Tricyclic antidepressant)
PK: t½ 25 hours | Clearance: hepatic
Max Dose: 150 day
severe
AE: Anticholinergic effects (dry mouth, constipation, urinary retention), sedation, orthostatic hypotension, arrhythmia risk

Bupropion

Brand: Wellbutrin (US/EU) / Bupep (IN) / Buproton (BD)
Subclass: NDRI (Norepinephrine-Dopamine Reuptake Inhibitor)
PK: t½ 21 hours | Clearance: hepatic
Max Dose: 450 day
severe
AE: Insomnia, agitation, tremor, dry mouth, seizures (dose dependent)

Citalopram

Brand: Celexa (US) / Stalopam (IN) / Citadep (BD)
Subclass: SSRI (Selective serotonin reuptake inhibitor)
PK: t½ 35 hours | Clearance: hepatic
Max Dose: 40 day
moderate
AE: QT prolongation, sexual dysfunction, nausea, insomnia

Clomipramine

Brand: Anafranil (US/EU) / Clonil (IN) / Clomicalm (BD)
Subclass: TCA (Tricyclic antidepressant)
PK: t½ 32 hours | Clearance: hepatic
Max Dose: 250 day
severe
AE: Sexual dysfunction, weight gain, constipation, arrhythmias, seizure threshold lowering

Duloxetine

Brand: Cymbalta (US/EU) / Duzela (IN) / Dulox (BD)
Subclass: SNRI (Serotonin-norepinephrine reuptake inhibitor)
PK: t½ 12 hours | Clearance: hepatic
Max Dose: 120 day
moderate
AE: Nausea, dry mouth, constipation, insomnia, sexual dysfunction, increased sweating, hepatotoxicity risk

Escitalopram

Brand: Lexapro (US/EU) / Nexito (IN) / Espram (BD)
Subclass: SSRI (Selective serotonin reuptake inhibitor)
PK: t½ 27 hours | Clearance: hepatic
Max Dose: 20 day
moderate
AE: Insomnia, nausea, headache, sexual dysfunction

Fluoxetine

Brand: Prozac (US/EU) / Flunil (IN) / Flux (BD)
Subclass: SSRI (Selective serotonin reuptake inhibitor)
PK: t½ 96 hours | Clearance: hepatic
Max Dose: 80 day
moderate
AE: Insomnia, anxiety activation, GI upset, sexual dysfunction

Imipramine

Brand: Tofranil (US/EU) / Depsonil (IN) / Imipra (BD)
Subclass: TCA (Tricyclic antidepressant)
PK: t½ 20 hours | Clearance: hepatic
Max Dose: 200 day
severe
AE: Anticholinergic effects, sedation, orthostatic hypotension, arrhythmias

Mirtazapine

Brand: Remeron (US/EU) / Mirtaz (IN) / Remer (BD)
Subclass: NaSSA (Noradrenergic and specific serotonergic antidepressant)
PK: t½ 30 hours | Clearance: hepatic
Max Dose: 45 day
moderate
AE: Weight gain, increased appetite, sedation, dry mouth

Nortriptyline

Brand: Pamelor (US/EU) / Nortrilop (IN) / Nortrip (BD)
Subclass: TCA (Tricyclic antidepressant)
PK: t½ 30 hours | Clearance: hepatic
Max Dose: 100 day
moderate
AE: Dry mouth, constipation, arrhythmia risk, dizziness, sedation

Paroxetine

Brand: Paxil (US/EU) / Paro-20 (IN) / Paxtin (BD)
Subclass: SSRI (Selective serotonin reuptake inhibitor)
PK: t½ 21 hours | Clearance: hepatic
Max Dose: 50 day
moderate
AE: Dry mouth, constipation, weight gain, sexual dysfunction, withdrawal symptoms on abrupt cessation

Sertraline

Brand: Zoloft (US/EU) / Serlift (IN) / Sertral (BD)
Subclass: SSRI (Selective serotonin reuptake inhibitor)
PK: t½ 26 hours | Clearance: hepatic
Max Dose: 200 day
moderate
AE: GI upset, insomnia, sexual dysfunction, headache, agitation

Venlafaxine

Brand: Effexor (US/EU) / Venlor (IN) / Venlafax (BD)
Subclass: SNRI (Serotonin-norepinephrine reuptake inhibitor)
PK: t½ 11 hours | Clearance: hepatic
Max Dose: 225 day
moderate
AE: Hypertension (dose-related), insomnia, nausea, sexual dysfunction, withdrawal symptoms