Anticancer Class

Abemaciclib

Brand: Verzenio

Subclass: CDK4/6 inhibitor

PK: t½ 18 hours | Clearance: hepatic
Max Dose: 300 day

severe
AE: Diarrhoea, neutropenia, fatigue

Ado-Trastuzumab Emtansine

Brand: Kadcyla (global) / T-DM1 (IN/BD)

Subclass: HER2 ADC (trastuzumab + DM1)

PK: t½ 96 hours | Clearance: hepatic
Max Dose: 10 day

severe
AE: Hepatotoxicity, thrombocytopenia, peripheral neuropathy, pneumonitis

Afatinib

Brand: Giotrif (global) / Afatinib (IN/BD)

Subclass: EGFR/HER2 irreversible TKI

PK: t½ 37 hours | Clearance: renal
Max Dose: 50 day

moderate
AE: Rash, diarrhoea, stomatitis

Alectinib

Brand: Alecensa (global)

Subclass: ALK inhibitor (2nd generation)

PK: t½ 32.5 hours | Clearance: hepatic
Max Dose: 1200 day

moderate
AE: Constipation, myalgia, elevated CPK, hepatotoxicity

Atezolizumab

Brand: Tecentriq (global) / Atezolizumab (IN/BD)

Subclass: PD-L1 Immune Checkpoint Inhibitor

PK: t½ 648 hours | Clearance: hepatic
Max Dose: 1200 day

life-threatening
AE: Immune-mediated pneumonitis, colitis, hepatitis, endocrinopathies

Avelumab

Brand: Bavencio (global) / Avelumab (IN/BD)

Subclass: PD-L1 Immune Checkpoint Inhibitor

PK: t½ 156 hours | Clearance: other
Max Dose: 10 day

life-threatening
AE: Immune pneumonitis, hepatitis, colitis; infusion reactions common

Bevacizumab

Brand: Avastin (global) / Bevacizumab (IN/BD)

Subclass: VEGF monoclonal antibody

PK: t½ 480 hours | Clearance: hepatic
Max Dose: 15 day

life-threatening
AE: Hypertension, proteinuria, arterial thromboembolism, GI perforation

Binimetinib

Brand: Mektovi (global)

Subclass: MEK inhibitor

PK: t½ 9 hours | Clearance: hepatic
Max Dose: 90 day

severe
AE: Retinal pigment epithelial detachment, CPK elevations, hepatotoxicity, diarrhea

Brigatinib

Brand: Alunbrig (global)

Subclass: ALK inhibitor (2nd gen)

PK: t½ 26 hours | Clearance: hepatic
Max Dose: 180 day

severe
AE: Pneumonitis (early onset), hypertension, visual disturbances, hyperglycemia, myalgia

Capecitabine

Brand: Xeloda (global)

Subclass: Antimetabolite (oral prodrug of 5-FU)

PK: t½ 0.75 hours | Clearance: hepatic

severe
AE: Diarrhea, hand-foot syndrome, mucositis, fatigue, cardiotoxicity (rare)

Capmatinib

Brand: Tabrecta (global)

Subclass: MET inhibitor

PK: t½ 6.5 hours | Clearance: hepatic
Max Dose: 800 day

moderate
AE: Peripheral edema, nausea, fatigue, photosensitivity, ILD/pneumonitis

Carboplatin

Brand: Paraplatin (global)

Subclass: Platinum compound (DNA crosslinker)

PK: t½ 5 hours | Clearance: renal

moderate
AE: Myelosuppression (especially thrombocytopenia), nausea/vomiting, less nephrotoxicity than cisplatin

Cemiplimab

Brand: Libtayo (global)

Subclass: PD-1 monoclonal antibody

PK: t½ 19 days | Clearance: hepatic

severe
AE: Immune mediated pneumonitis, colitis, hepatitis, endocrinopathies

Ceritinib

Brand: Zykadia (global)

Subclass: ALK inhibitor (2nd generation)

PK: t½ 1.7 days | Clearance: hepatic
Max Dose: 450 day

moderate
AE: Severe GI toxicity (diarrhea, nausea), hepatotoxicity, QT prolongation, hyperglycemia

Cisplatin

Brand: Platinol (global)

Subclass: Platinum compound (DNA crosslinker)

PK: t½ 70 hours | Clearance: renal

severe
AE: Nephrotoxicity, ototoxicity, peripheral neuropathy, severe nausea/vomiting

Cobimetinib

Brand: Cotellic (global)

Subclass: MEK inhibitor

PK: t½ 44 hours | Clearance: hepatic
Max Dose: 60 day

severe
AE: Rhabdomyolysis, CPK elevation, serous retinopathy, diarrhea

Crizotinib

Brand: Xalkori (global)

Subclass: ALK / ROS1 inhibitor (1st gen)

PK: t½ 42 hours | Clearance: hepatic
Max Dose: 500 day

moderate
AE: Visual disturbances (common), QT prolongation, hepatotoxicity, GI upset, bradycardia

Cytarabine

Brand: DepoCyt (liposomal) / Cytarabine generic

Subclass: Antimetabolite (pyrimidine analogue)

PK: t½ 1.5 hours | Clearance: hepatic

severe
AE: Myelosuppression, cerebellar toxicity (high dose), conjunctivitis

Dabrafenib

Brand: Tafinlar (global)

Subclass: BRAF inhibitor (V600E/K)

PK: t½ 8 hours | Clearance: hepatic
Max Dose: 300 day

moderate
AE: Fever, hyperglycemia, skin reactions, uveitis

Dasatinib

Brand: Sprycel (US/EU) / Dasatinib (IN/BD)

Subclass: BCR-ABL Tyrosine Kinase Inhibitor

PK: t½ 4 hours | Clearance: hepatic
Max Dose: 140 day

severe
AE: Myelosuppression, pleural effusion, pulmonary hypertension

Daunorubicin

Brand: Cerubidine (global) / Daunoblastin (IN/BD)

Subclass: Anthracycline (topoisomerase II inhibitor)

PK: t½ 19 hours | Clearance: hepatic

life-threatening
AE: Myelosuppression, cardiomyopathy, mucositis, red/orange urine

Docetaxel

Brand: Taxotere (global) / Daxotel (IN/BD)

Subclass: Taxane (microtubule stabilizer)

PK: t½ 11 hours | Clearance: hepatic

severe
AE: Neutropenia, peripheral edema/fluid retention, mucositis, nail changes

Durvalumab

Brand: Imfinzi (global) / Durvalumab (IN/BD)

Subclass: PD-L1 Immune Checkpoint Inhibitor

PK: t½ 432 hours | Clearance: hepatic
Max Dose: 1500 day

life-threatening
AE: Immune pneumonitis, hepatitis, colitis, endocrinopathy

Encorafenib

Brand: Braftovi (global)

Subclass: BRAF inhibitor (V600E/K)

PK: t½ 6 hours | Clearance: hepatic
Max Dose: 450 day

moderate
AE: QT prolongation, ocular toxicity, hepatotoxicity, fatigue

Entrectinib

Brand: Rozlytrek (global)

Subclass: NTRK / ROS1 inhibitor

PK: t½ 20 hours | Clearance: hepatic
Max Dose: 600 day

moderate
AE: Edema, dizziness, cognitive changes, weight gain, hepatotoxicity, CHF risk

Epirubicin

Brand: Ellence (global)

Subclass: Anthracycline (topoisomerase II inhibitor)

PK: t½ 30 hours | Clearance: hepatic

life-threatening
AE: Myelosuppression, cardiotoxicity, mucositis, alopecia

Erlotinib

Brand: Tarceva (US/EU) / Erlotinib (IN/BD)

Subclass: EGFR Tyrosine Kinase Inhibitor

PK: t½ 36 hours | Clearance: hepatic
Max Dose: 150 day

severe
AE: Rash, diarrhoea, hepatotoxicity, interstitial lung disease (rare)

Fluorouracil

Brand: Adrucil (global) / 5-FU (standard generic)

Subclass: Antimetabolite (pyrimidine analogue)

PK: t½ 0.25 hours | Clearance: hepatic

severe
AE: Myelosuppression, mucositis, cardiotoxicity (rare), diarrhea, hand-foot syndrome

Gefitinib

Brand: Iressa (US/EU/IN)

Subclass: EGFR Tyrosine Kinase Inhibitor

PK: t½ 48 hours | Clearance: hepatic
Max Dose: 250 day

moderate
AE: Rash, diarrhoea, hepatotoxicity

Gemcitabine

Brand: Gemzar (global) / Gemcitabine (IN/BD generic)

Subclass: Antimetabolite (pyrimidine analogue)

PK: t½ 0.7 hours | Clearance: renal

moderate
AE: Myelosuppression, flu-like syndrome, hepatotoxicity, pulmonary toxicity (rare)

Idarubicin

Brand: Idamycin (global)

Subclass: Anthracycline (topoisomerase II inhibitor)

PK: t½ 22 hours | Clearance: hepatic

life-threatening
AE: Cardiotoxicity, myelosuppression, nausea/vomiting, mucositis

Imatinib

Brand: Gleevec (US/EU) / Imatinib (IN/BD)

Subclass: BCR-ABL Tyrosine Kinase Inhibitor

PK: t½ 18 hours | Clearance: hepatic
Max Dose: 800 day

moderate
AE: Fluid retention, edema, N/V, rash, cytopenias

Ipilimumab

Brand: Yervoy (global) / Ipilimumab (IN/BD)

Subclass: CTLA-4 Immune Checkpoint Inhibitor

PK: t½ 360 hours | Clearance: other
Max Dose: 3 day

life-threatening
AE: Severe immune-mediated colitis, hepatitis, dermatitis, endocrine failure

Lapatinib

Brand: Tykerb (global)

Subclass: HER2 / EGFR dual TKI

PK: t½ 14 hours | Clearance: hepatic
Max Dose: 1250 day

moderate
AE: Diarrhoea, hepatotoxicity, rash, cardiotoxicity

Larotrectinib

Brand: Vitrakvi (global)

Subclass: NTRK selective inhibitor

PK: t½ 3 hours | Clearance: hepatic
Max Dose: 200 day

moderate
AE: Dizziness, fatigue, nausea, hepatotoxicity

Lenalidomide

Brand: Revlimid (global)

Subclass: Immunomodulatory agent (IMiD)

PK: t½ 3 hours | Clearance: renal

severe
AE: Myelosuppression, thrombosis, fatigue, rash

Lorlatinib

Brand: Lorbrena (global)

Subclass: ALK inhibitor (3rd gen)

PK: t½ 24 hours | Clearance: hepatic
Max Dose: 100 day

moderate
AE: Cognitive/mood changes, hyperlipidemia, neuropathy, edema, weight gain

Methotrexate

Brand: Trexall (global) / Methotrexate (IN/BD generic)

Subclass: Antimetabolite (antifolate)

PK: t½ 8 hours | Clearance: renal

severe
AE: Myelosuppression, hepatotoxicity, mucositis, nephrotoxicity at high dose

Neratinib

Brand: Nerlynx (global)

Subclass: HER2 irreversible TKI

PK: t½ 17 hours | Clearance: hepatic
Max Dose: 240 day

severe
AE: Severe diarrhoea, hepatotoxicity, nausea, stomatitis

Nilotinib

Brand: Tasigna (US/EU) / Nilotinib (IN/BD)

Subclass: BCR-ABL Tyrosine Kinase Inhibitor

PK: t½ 17 hours | Clearance: hepatic
Max Dose: 800 day

life-threatening
AE: QT prolongation, sudden death risk, hyperglycemia, hepatic toxicity

Niraparib

Brand: Zejula (global) / Niraparib (IN/BD)

Subclass: PARP inhibitor

PK: t½ 36 hours | Clearance: hepatic
Max Dose: 300 day

moderate
AE: Thrombocytopenia, hypertension, nausea, fatigue

Olaparib

Brand: Lynparza (global) / Olaparib (IN/BD)

Subclass: PARP inhibitor

PK: t½ 12 hours | Clearance: hepatic
Max Dose: 600 day

moderate
AE: Anemia, neutropenia, nausea, fatigue

Osimertinib

Brand: Tagrisso (global)

Subclass: EGFR TKI (3rd gen)

PK: t½ 48 hours | Clearance: hepatic
Max Dose: 80 day

severe
AE: QT prolongation, ILD/pneumonitis, diarrhea, rash

Oxaliplatin

Brand: Eloxatin (global)

Subclass: Platinum compound (DNA crosslinker)

PK: t½ 14 hours | Clearance: renal

moderate
AE: Peripheral neuropathy (cold induced), nausea/vomiting, diarrhea, myelosuppression

Paclitaxel

Brand: Taxol (global) / Paclitax (IN/BD)

Subclass: Taxane (microtubule stabilizer)

PK: t½ 20 hours | Clearance: hepatic

severe
AE: Neutropenia, peripheral neuropathy, hypersensitivity reactions, alopecia

Palbociclib

Brand: Ibrance (US/EU) / Palbociclib (IN/BD)

Subclass: CDK4/6 inhibitor

PK: t½ 29 hours | Clearance: hepatic
Max Dose: 125 day

severe
AE: Neutropenia, infections, stomatitis, fatigue

Pembrolizumab

Brand: Keytruda (global)

Subclass: PD-1 Immune Checkpoint Inhibitor

PK: t½ 528 hours | Clearance: hepatic
Max Dose: 200 day

life-threatening
AE: Immune-mediated pneumonitis, colitis, hepatitis, endocrinopathies, thyroid dysfunction

Pemetrexed

Brand: Alimta (global)

Subclass: Antimetabolite (multitargeted antifolate)

PK: t½ 3.5 hours | Clearance: renal

moderate
AE: Myelosuppression, fatigue, rash, mucositis

Pertuzumab

Brand: Perjeta (global) / Pertuzumab (IN/BD)

Subclass: HER2 monoclonal antibody

PK: t½ 432 hours | Clearance: hepatic
Max Dose: 420 day

severe
AE: Diarrhoea, rash, neutropenia, infusion reactions; potential cardiotoxicity (esp. with trastuzumab); embryo-fetal toxicity

Pomalidomide

Brand: Pomalyst (global)

Subclass: Immunomodulatory agent (IMiD)

PK: t½ 7.5 hours | Clearance: hepatic

severe
AE: Myelosuppression, fatigue, thrombosis risk, rash

Pralsetinib

Brand: Gavreto (global)

Subclass: RET inhibitor

PK: t½ 22 hours | Clearance: hepatic
Max Dose: 400 day

severe
AE: Interstitial lung disease/pneumonitis, hypertension, hepatotoxicity, neutropenia

Ribociclib

Brand: Kisqali

Subclass: CDK4/6 inhibitor

PK: t½ 32 hours | Clearance: hepatic
Max Dose: 600 day

severe
AE: Neutropenia, hepatotoxicity, QT prolongation

Rucaparib

Brand: Rubraca (global) / Rucaparib (IN/BD)

Subclass: PARP inhibitor

PK: t½ 17 hours | Clearance: hepatic
Max Dose: 600 day

moderate
AE: Nausea, vomiting, anemia, increased ALT/AST

Selpercatinib

Brand: Retevmo (global)

Subclass: RET inhibitor

PK: t½ 32 hours | Clearance: hepatic
Max Dose: 320 day

moderate
AE: Hypertension, hepatotoxicity, QT prolongation, dry mouth, edema

Talazoparib

Brand: Talzenna (global) / Talazoparib (IN/BD)

Subclass: PARP inhibitor

PK: t½ 90 hours | Clearance: hepatic
Max Dose: 1 day

moderate
AE: Anemia, neutropenia, thrombocytopenia, fatigue

Thalidomide

Brand: Thalomid (global)

Subclass: Immunomodulatory agent (IMiD)

PK: t½ 6 hours | Clearance: hepatic

life-threatening
AE: Sedation, constipation, peripheral neuropathy, thrombosis risk

Trametinib

Brand: Mekinist (global)

Subclass: MEK inhibitor

PK: t½ 4 days | Clearance: hepatic
Max Dose: 2 day

severe
AE: Cardiomyopathy, retinopathy, diarrhea, hypertension, ILD

Trastuzumab

Brand: Herceptin (global) / Trastuzumab (IN/BD)

Subclass: HER2 monoclonal antibody

PK: t½ 684 hours | Clearance: hepatic
Max Dose: 6 day

severe
AE: Cardiomyopathy, infusion reactions, pulmonary toxicity

Tucatinib

Brand: Tukysa (global)

Subclass: HER2 selective TKI

PK: t½ 13 hours | Clearance: hepatic
Max Dose: 600 day

moderate
AE: Hepatotoxicity, diarrhoea, stomatitis, fatigue

Vemurafenib

Brand: Zelboraf (global)

Subclass: BRAF inhibitor (V600E)

PK: t½ 57 hours | Clearance: hepatic
Max Dose: 1920 day

moderate
AE: Photosensitivity, arthralgia, rash, QT prolongation

Vinblastine

Brand: Velbe (global) / Cytoblastin (IN/BD)

Subclass: Vinca alkaloid (microtubule inhibitor)

PK: t½ 25 hours | Clearance: hepatic

severe
AE: Myelosuppression, hair loss, nausea/vomiting

Vincristine

Brand: Cytocristin (IN/BD) / Oncovin (global)

Subclass: Vinca alkaloid (microtubule inhibitor)

PK: t½ 85 hours | Clearance: hepatic

severe
AE: Peripheral neuropathy, constipation/ileus, jaw pain, cranial nerve palsies