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Endocrine Class

Anastrozole

Brand: Arimidex (global)
Subclass: Aromatase inhibitor
PK: t½ 50 hours | Clearance: hepatic
Max Dose: 1 day
moderate
AE: Bone loss, hot flashes, arthralgias

Cabergoline

Brand: Cabaser
Subclass: Dopamine agonist
PK: t½ 65 hours | Clearance: hepatic
Max Dose: 1 day
moderate
AE: Nausea, dizziness, hypotension

Clomiphene

Brand: Clomid
Subclass: SERM
PK: t½ 5 days | Clearance: hepatic
Max Dose: 150 day
moderate
AE: Ovarian enlargement, hot flashes, visual disturbances

Exemestane

Brand: Aromasin (global)
Subclass: Aromatase inhibitor (steroidal)
PK: t½ 27 hours | Clearance: hepatic
Max Dose: 25 day
moderate
AE: Hot flashes, arthralgia, fatigue, bone loss

Fulvestrant

Brand: Faslodex (global)
Subclass: SERD
PK: t½ 40 days | Clearance: hepatic
moderate
AE: Injection site pain, liver enzyme elevation, hot flashes

HCG

Brand: Ovidrel
Subclass: Gonadotropin
PK: t½ 36 hours | Clearance: renal
moderate
AE: Ovarian hyperstimulation, headache, abdominal pain

Letrozole

Brand: Femara
Subclass: Aromatase Inhibitor
PK: t½ 2 days | Clearance: hepatic
Max Dose: 7.5 day
moderate
AE: Hot flashes, headache, arthralgia, fatigue

Megestrol Acetate

Brand: Megace (US/EU) / Megetrol (IN) / Megace (BD)
Subclass: Progestin (appetite stimulant)
PK: t½ 20 hours | Clearance: hepatic
Max Dose: 800 day
severe
AE: Thromboembolism, adrenal suppression, edema, hyperglycemia

Tamoxifen

Brand: Nolvadex
Subclass: SERM
PK: t½ 6 days | Clearance: hepatic