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Gastrointestinal Class

Mesalazine

Brand: Asacol (US/EU) / Pentasa (US/EU) / Mesacol (IN) / Salofalk (BD)
Subclass: 5-Aminosalicylic acid (anti-inflammatory)
PK: t½ 1 hours | Clearance: renal
Max Dose: 4800 day
moderate
AE: Headache, nausea, abdominal pain, diarrhea; rare nephrotoxicity, myocarditis

Sulfasalazine

Brand: Azulfidine (US/EU) / Salazopyrin (EU) / Saaz (IN) / SulfaSalazine (BD)
Subclass: Azo-linked 5-ASA prodrug
PK: t½ 7 hours | Clearance: mixed
Max Dose: 4000 day
moderate
AE: Nausea, headache, rash, reversible oligospermia; hemolysis in G6PD deficiency

Ursodeoxycholic Acid

Brand: Urso / Ursocol / Udiliv / Urshol / Urshocal
Subclass: Bile acid / Hepatoprotective agent
PK: t½ 4 hours | Clearance: hepatic
Max Dose: 1500 day
moderate
AE: Diarrhea, abdominal discomfort, nausea, pruritus (occasionally), rare worsening of liver tests