Sedative/Hypnotic Class
Eszopiclone
Brand: Lunesta (US) / Eszopira (IN) / Zpix (BD)
Subclass: Non-benzodiazepine Z-drug (GABA-A modulator)
PK:
t½ 6 hours | Clearance: hepatic
Max Dose: 3 day
Max Dose: 3 day
moderate
AE: Dysgeusia (metallic/bitter taste), dizziness, next-day impairment, dry mouth
AE: Dysgeusia (metallic/bitter taste), dizziness, next-day impairment, dry mouth
Midazolam
Brand: Versed (US/EU) / Mezolam (IN) / Midatin (BD)
Subclass: Benzodiazepine sedative (GABA-A positive allosteric modulator)
PK:
t½ 3 hours | Clearance: hepatic
Max Dose: 10 day
Max Dose: 10 day
severe
AE: Severe respiratory depression, hypotension, apnea, amnesia
AE: Severe respiratory depression, hypotension, apnea, amnesia
Temazepam
Brand: Restoril (US) / Temsun (IN) / Restozam (BD)
Subclass: Benzodiazepine hypnotic (GABA-A positive allosteric modulator)
PK:
t½ 10 hours | Clearance: hepatic
Max Dose: 30 day
Max Dose: 30 day
moderate
AE: Daytime drowsiness, impaired coordination, memory impairment, dependency
AE: Daytime drowsiness, impaired coordination, memory impairment, dependency
Zolpidem
Brand: Ambien (US) / Stilnox (EU) / Zolfresh (IN) / Zolmate (BD)
Subclass: Non-benzodiazepine Z-drug (GABA-A modulator)
PK:
t½ 2.5 hours | Clearance: hepatic
Max Dose: 10 day
Max Dose: 10 day
moderate
AE: Sleepwalking, complex sleep behaviors, next-day impairment, dizziness
AE: Sleepwalking, complex sleep behaviors, next-day impairment, dizziness