Captopril
Brand: Capoten (US/EU) / Captol (IN) / Captopril (BD)
Antihypertensive
ACE inhibitor (short-acting)
Pharmacokinetics
| Half-life | 2 hours |
| Tmax | 0.75 h |
| Bioavailability | 65 % (approx) |
| Protein Binding | 25 % |
| Volume of Distribution | 0.8 L/kg (approx) |
| Clearance Route | renal |
| Active Metabolites | no |
| Notes | Short-acting ACE inhibitor; sulfhydryl group responsible for taste disturbance and rash; requires multiple daily dosing. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Dry cough, hyperkalemia, skin rash, dysgeusia (metallic taste), hypotension, angioedema
Contraindications:
Pregnancy, bilateral renal artery stenosis, prior ACEI-induced angioedema
Precautions:
Monitor renal function and potassium; dosing TID due to short half-life; caution in volume-depleted patients