Azathioprine
Brand: Imuran (US/EU) / Azoran (IN) / Azathioprine (BD)
Immunosuppressant
Thiopurine antimetabolite
Pharmacokinetics
| Half-life | 5 hours |
| Tmax | 2 h |
| Bioavailability | 90 % (approx) |
| Protein Binding | 30 % |
| Volume of Distribution | 0.6 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Converted to 6-MP; TPMT/NUDT15 activity determines toxicity risk. |
⚠️ Safety & Warnings
Severity: Severe
Adverse Effects:
Myelosuppression, hepatotoxicity, pancreatitis, infections
Contraindications:
TPMT deficiency, active malignancy
Precautions:
Check TPMT/NUDT15 before therapy; monitor CBC and LFT