Cytarabine

Brand: DepoCyt (liposomal) / Cytarabine generic

Anticancer Antimetabolite (pyrimidine analogue)

Chemistry

Molecular Formula	C9H13N3O5
PubChem	CID: 6253 Open in PubChem

Structure

Half-life	1.5 hours
Clearance Route	hepatic
Active Metabolites	yes
Notes	High-dose cytarabine causes cerebellar toxicity; monitor neuro exam in HD-AraC protocols.

Severity: Severe

Adverse Effects:
Myelosuppression, cerebellar toxicity (high dose), conjunctivitis

Contraindications:
Severe hepatic dysfunction

Precautions:
Use steroid eye drops prophylaxis with high-dose AraC; frequent neuro check needed