Cisplatin

Brand: Platinol (global)

Anticancer Platinum compound (DNA crosslinker)

Chemistry

Molecular Formula	Cl2H6N2Pt
PubChem	CID: 5702198 Open in PubChem

Structure

Half-life	70 hours
Clearance Route	renal
Active Metabolites	no
Notes	Severe nephrotoxicity; requires aggressive hydration; ototoxicity common especially in children.

Severity: Severe

Adverse Effects:
Nephrotoxicity, ototoxicity, peripheral neuropathy, severe nausea/vomiting

Contraindications:
Significant renal impairment

Precautions:
Pre- and post-hydration mandatory; avoid if GFR low; monitor electrolytes