Noradrenaline
Brand: Norepinephrine (US/EU) / Norad (IN/BD)
Emergency
Catecholamine vasopressor
Pharmacokinetics
| Half-life | 0.0417 hours |
| Tmax | 0.05 h |
| Bioavailability | 100 % (approx) |
| Protein Binding | 0 % |
| Volume of Distribution | 0.2 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Very short t½; effect stops within minutes of stopping infusion. Central line preferred; avoid extravasation. |
⚠️ Safety & Warnings
Severity: Life-threatening
Adverse Effects:
Tachyarrhythmias, ischemia, peripheral vasoconstriction/necrosis if extravasated
Contraindications:
Mesenteric/limb ischemia (relative)
Precautions:
Use central line; treat extravasation with phentolamine if occurs; close hemodynamic monitoring