Bedaquiline
Brand: Sirturo (global)
Antibiotic
Anti-TB (ATP synthase inhibitor)
Pharmacokinetics
| Half-life | 164 days |
| Tmax | 5 h |
| Bioavailability | 55 % (approx) |
| Protein Binding | 99 % |
| Volume of Distribution | 164 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Extremely long half-life (~5.5 months). Monitor QT interval. Avoid combining with strong CYP3A inducers/inhibitors. |
⚠️ Safety & Warnings
Severity: Life-threatening
Adverse Effects:
QT prolongation, hepatotoxicity, nausea, arthralgia
Contraindications:
Baseline QT prolongation
Precautions:
ECG monitoring mandatory; baseline and monthly LFTs