Rifampicin
Brand: Rimactane (US/EU) / Rcin (IN/BD)
Antibiotic
Anti-TB (Rifamycin)
Pharmacokinetics
| Half-life | 3 hours |
| Tmax | 2 h |
| Bioavailability | 90 % (approx) |
| Protein Binding | 80 % |
| Volume of Distribution | 0.9 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Strong CYP450 inducer; orange discoloration of body fluids is normal. |
⚠️ Safety & Warnings
Severity: Severe
Adverse Effects:
Hepatotoxicity, orange urine/tears/sweat, flu-like syndrome
Contraindications:
Severe hepatic impairment
Precautions:
Monitor LFTs; many drug interactions due to CYP induction (OCP, warfarin, many others)