Metronidazole
Brand: Flagyl (US/EU) / Metrogyl (IN) / Metrix (BD)
Antibiotic
Nitroimidazole (anaerobes, protozoa)
Pharmacokinetics
| Half-life | 8 hours |
| Tmax | 1 h |
| Bioavailability | 99 % (approx) |
| Protein Binding | 20 % |
| Volume of Distribution | 0.6 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Disulfiram-like reaction with alcohol—avoid during and 48–72 h after; metallic taste common. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Metallic taste, GI upset, neuropathy (prolonged), disulfiram-like reaction with alcohol
Contraindications:
Concomitant disulfiram (within 14 days)
Precautions:
Strict alcohol avoidance; caution prolonged courses (neuropathy)