Doxycycline
Brand: Vibramycin (US/EU) / Doxy-1 (IN) / Doxicap (BD)
Antibiotic
Tetracycline
Pharmacokinetics
| Half-life | 18 hours |
| Tmax | 2 h |
| Bioavailability | 90 % (approx) |
| Protein Binding | 80 % |
| Volume of Distribution | 0.7 L/kg (approx) |
| Clearance Route | mixed |
| Active Metabolites | no |
| Notes | Avoid simultaneous iron/calcium/antacids; photosensitivity counseling. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
GI upset, photosensitivity, esophagitis if taken lying down
Contraindications:
Pregnancy, children <8 years (tooth discoloration)
Precautions:
Take with water; remain upright 30 min; avoid dairy/iron around dosing
--- Antimalarial Precautions ---
Use sun protection (photosensitivity);
Avoid in pregnancy & children <8 years;
Take with water to prevent esophagitis.