Ceftriaxone
Brand: Rocephin (US/EU) / Ceftrion (IN/BD)
Antibiotic
Cephalosporin 3rd generation (parenteral)
Pharmacokinetics
| Half-life | 8 hours |
| Tmax | 2 h |
| Bioavailability | 100 % (approx) |
| Protein Binding | 95 % |
| Volume of Distribution | 0.2 L/kg (approx) |
| Clearance Route | mixed |
| Active Metabolites | no |
| Notes | Very long half-life among cephalosporins; often once-daily dosing. |
⚠️ Safety & Warnings
Severity: Severe
Adverse Effects:
Biliary sludging, diarrhea, injection-site pain
Contraindications:
Neonates (risk of bilirubin displacement)
Precautions:
Avoid mixing with calcium infusions in neonates; monitor LFTs in long use