Insulin Glargine U100

Brand: Lantus (US/EU) / Basalog (IN) / Basugine (BD)

Antidiabetic Basal insulin (long-acting)

Chemistry

Molecular Formula

Peptide

Structure

Half-life	12 hours
Tmax	12 h
Bioavailability	60 % (approx)
Protein Binding	0 %
Volume of Distribution	0.1 L/kg (approx)
Clearance Route	other
Active Metabolites	no
Notes	Dosed in units (not mg). PK reflects depot release; flat ~24h effect. Use clinical titration, not calculator max-dose logic.

Severity: Severe

Adverse Effects:
Hypoglycemia, weight gain, lipodystrophy at injection site

Contraindications:
Hypoglycemia unawareness (relative)

Precautions:
Educate injection rotation and hypo management; adjust with renal/hepatic impairment; avoid mixing in same syringe