Amantadine
Brand: Symmetrel (US/EU) / Amanex (IN) / Amaflex (BD)
Antiparkinson
NMDA receptor antagonist
Pharmacokinetics
| Half-life | 16 hours |
| Tmax | 3 h |
| Bioavailability | 90 % (approx) |
| Protein Binding | 67 % |
| Volume of Distribution | 3 L/kg (approx) |
| Clearance Route | renal |
| Active Metabolites | no |
| Notes | Useful for dyskinesia caused by levodopa; antiviral activity is historical. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Livedo reticularis (mottled skin), ankle edema, confusion, dizziness
Contraindications:
Severe renal impairment
Precautions:
Reduce dose in renal dysfunction; monitor for confusion especially in elderly