Lamotrigine
Brand: Lamictal (US/EU) / Lamitor (IN) / Lamotrin (BD)
Anticonvulsant
Sodium channel blocker / glutamate release inhibitor
Pharmacokinetics
| Half-life | 29 hours |
| Tmax | 2 h |
| Bioavailability | 98 % (approx) |
| Protein Binding | 55 % |
| Volume of Distribution | 1.2 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | no |
| Notes | Must be titrated slowly to avoid rash; dose is lower when on valproate (increases lamotrigine levels). |
⚠️ Safety & Warnings
Severity: Severe
Adverse Effects:
Rash (can progress to SJS/TEN), dizziness, diplopia, headache
Contraindications:
Hypersensitivity history to lamotrigine
Precautions:
Start low and titrate slowly; avoid rapid dose escalation; caution if combined with valproate