Quetiapine
Brand: Seroquel (US/EU) / Quitipin (IN) / Quetpin (BD)
Antipsychotic
Atypical antipsychotic (D2/5-HT2A antagonist)
Pharmacokinetics
| Half-life | 7 hours |
| Tmax | 1.5 h |
| Bioavailability | 9 % (approx) |
| Protein Binding | 83 % |
| Volume of Distribution | 10 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Significant sedation especially at low doses; monitor metabolic parameters. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Sedation, orthostatic hypotension, weight gain, hyperglycemia, dyslipidemia
Contraindications:
Known hypersensitivity
Precautions:
Avoid using as routine sleeping pill; monitor metabolic labs; sedation may impair driving.