Lorazepam
Brand: Ativan (US/EU) / Lorax (IN) / Loram (BD)
Anxiolytic
Benzodiazepine anxiolytic (GABA-A positive allosteric modulator)
Pharmacokinetics
| Half-life | 14 hours |
| Tmax | 2 h |
| Bioavailability | 90 % (approx) |
| Protein Binding | 91 % |
| Volume of Distribution | 1.3 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | no |
| Notes | Preferred benzodiazepine in elderly and hepatic dysfunction; used IV in status epilepticus. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Sedation, confusion, impaired coordination, dependence
Contraindications:
Severe respiratory insufficiency
Precautions:
Use the lowest effective dose; avoid alcohol and opioids; taper gradually if long-term use.