Dipyridamole

Brand: Persantine (US/EU) / Pdyl (IN) / Aggrenox-combo (BD)

Antiplatelet PDE inhibitor (vasodilatory antiplatelet)

Chemistry

Molecular Formula	C24H40N8O4
PubChem	CID: 3108 Open in PubChem

Structure

Half-life	10 hours
Tmax	2 h
Bioavailability	37 % (approx)
Protein Binding	99 %
Volume of Distribution	2 L/kg (approx)
Clearance Route	hepatic
Active Metabolites	no
Notes	Used primarily in combination therapy; vasodilatory headaches common; long half-life supports BID dosing.

Severity: Mild

Adverse Effects:
Headache, flushing, hypotension, dizziness, GI upset

Contraindications:
Severe hypotension, unstable angina (caution), hypersensitivity

Precautions:
Use with aspirin for stroke prevention; avoid in symptomatic hypotension; may worsen angina initially due to coronary steal