Amiloride

Brand: Midamor (US/EU) / Amifru (IN) / Amilor (BD)

Antihypertensive Potassium-sparing diuretic (Sodium channel blocker)

Chemistry

Molecular Formula	C6H8ClN7O
PubChem	CID: 16231 Open in PubChem

Structure

Half-life	6 hours
Tmax	3 h
Bioavailability	50 % (approx)
Protein Binding	40 %
Volume of Distribution	5 L/kg (approx)
Clearance Route	renal
Active Metabolites	no
Notes	Excreted unchanged in urine; duration of effect 24h; often combined with thiazides to minimize potassium loss; use caution in renal impairment.

Severity: Moderate

Adverse Effects:
Hyperkalemia, nausea, vomiting, headache, fatigue

Contraindications:
Anuria, severe renal impairment, hyperkalemia

Precautions:
Monitor serum potassium and renal function; avoid potassium supplements or ACE inhibitors concurrently