Carvedilol
Brand: Coreg (US/EU) / Carloc (IN) / Dilatrend (BD)
Antihypertensive
Alpha and beta blocker
Pharmacokinetics
| Half-life | 7 hours |
| Tmax | 1.5 h |
| Bioavailability | 25 % (approx) |
| Protein Binding | 98 % |
| Volume of Distribution | 1.5 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Undergoes extensive hepatic metabolism (CYP2D6, CYP2C9); high protein binding; reduce dose in hepatic impairment. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Hypotension, bradycardia, dizziness, fatigue, orthostatic symptoms
Contraindications:
Severe hepatic impairment, bronchial asthma, marked bradycardia, AV block
Precautions:
Monitor for postural hypotension during titration; caution in COPD, diabetes, and elderly