Losartan
Brand: Cozaar (US/EU) / Losar (IN) / Losakind (IN) / Lorista (BD)
Antihypertensive
Angiotensin II receptor blocker (ARB)
Pharmacokinetics
| Half-life | 9 hours |
| Tmax | 1.5 h |
| Bioavailability | 33 % (approx) |
| Protein Binding | 99 % |
| Volume of Distribution | 0.8 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Converted to active metabolite (EXP-3174) with longer duration; mild uricosuric effect beneficial in hypertensive patients with hyperuricemia. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Dizziness, hyperkalemia (less than ACEIs), renal function changes; rare angioedema
Contraindications:
Pregnancy, bilateral renal artery stenosis
Precautions:
Monitor serum potassium and renal function; preferred in ACEI intolerance due to cough