Fluoxetine
Brand: Prozac (US/EU) / Flunil (IN) / Flux (BD)
Antidepressant
SSRI (Selective serotonin reuptake inhibitor)
Pharmacokinetics
| Half-life | 96 hours |
| Tmax | 6 h |
| Bioavailability | 72 % (approx) |
| Protein Binding | 94 % |
| Volume of Distribution | 20 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Due to long half-life, tapering sometimes not required; strong CYP2D6 inhibitor. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Insomnia, anxiety activation, GI upset, sexual dysfunction
Contraindications:
Concurrent MAOI use; risk of serotonin syndrome
Precautions:
Avoid with tamoxifen due to CYP2D6 inhibition (reduces efficacy of tamoxifen); caution in bipolar disorder (risk of switch)