Thalidomide
Brand: Thalomid (global)
Anticancer
Immunomodulatory agent (IMiD)
Pharmacokinetics
| Half-life | 6 hours |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Strict pregnancy prevention program required; causes sedation + neuropathy. |
⚠️ Safety & Warnings
Severity: Life-threatening
Adverse Effects:
Sedation, constipation, peripheral neuropathy, thrombosis risk
Contraindications:
Pregnancy (absolute)
Precautions:
Requires REMS-like controlled distribution; consider anticoagulation in high-risk patients