Pemetrexed

Brand: Alimta (global)

Anticancer Antimetabolite (multitargeted antifolate)

Chemistry

Molecular Formula	C20H21N5O6
PubChem	CID: 44539 Open in PubChem

Structure

Half-life	3.5 hours
Clearance Route	renal
Active Metabolites	no
Notes	Folic acid + Vitamin B12 supplementation markedly reduces hematologic and GI toxicity.

Severity: Moderate

Adverse Effects:
Myelosuppression, fatigue, rash, mucositis

Contraindications:
Severe renal impairment

Precautions:
Mandatory folate + B12 supplementation; give dexamethasone to reduce rash risk