Gemcitabine

Brand: Gemzar (global) / Gemcitabine (IN/BD generic)

Anticancer Antimetabolite (pyrimidine analogue)

Chemistry

Molecular Formula	C9H11F2N3O4
PubChem	CID: 60750 Open in PubChem

Structure

Half-life	0.7 hours
Clearance Route	renal
Active Metabolites	yes
Notes	Given weekly or days 1+8 schedule; thrombocytopenia more prominent than anemia.

Severity: Moderate

Adverse Effects:
Myelosuppression, flu-like syndrome, hepatotoxicity, pulmonary toxicity (rare)

Contraindications:
Severe myelosuppression

Precautions:
Check CBC before each dose; caution in lung disease