Carboplatin

Brand: Paraplatin (global)

Anticancer Platinum compound (DNA crosslinker)

Chemistry

Molecular Formula	C6H12N2O4Pt
PubChem	CID: 5311050 Open in PubChem

Structure

Half-life	5 hours
Clearance Route	renal
Active Metabolites	no
Notes	Dose is calculated by Calvert formula: Dose(mg) = AUC × (GFR + 25). Adjust for renal insufficiency.

Severity: Moderate

Adverse Effects:
Myelosuppression (especially thrombocytopenia), nausea/vomiting, less nephrotoxicity than cisplatin

Contraindications:
Severe renal dysfunction

Precautions:
Check CBC before each cycle; adjust dose based on GFR