Docetaxel

Brand: Taxotere (global) / Daxotel (IN/BD)

Anticancer Taxane (microtubule stabilizer)

Chemistry

Molecular Formula	C43H53NO14
PubChem	CID: 148124 Open in PubChem

Structure

Half-life	11 hours
Clearance Route	hepatic
Active Metabolites	yes
Notes	Causes fluid retention → premedicate with dexamethasone; adjust dose if bilirubin elevated.

Severity: Severe

Adverse Effects:
Neutropenia, peripheral edema/fluid retention, mucositis, nail changes

Contraindications:
Severe liver impairment

Precautions:
Premedicate with steroids to reduce edema; monitor CBC and liver function