Dabrafenib

Brand: Tafinlar (global)

Anticancer BRAF inhibitor (V600E/K)

Chemistry

Molecular Formula	C23H20F3N5O2
PubChem	CID: 25308267 Open in PubChem

Structure

Half-life	8 hours
Tmax	2 h
Protein Binding	99 %
Clearance Route	hepatic
Active Metabolites	yes
Notes	Usually given with Trametinib. Strong CYP3A4 inducer: many interactions.

Severity: Moderate

Adverse Effects:
Fever, hyperglycemia, skin reactions, uveitis

Contraindications:
Severe uncontrolled cardiac disease

Precautions:
Monitor for fever (very common); manage dose interruptions as needed.