Alectinib

Brand: Alecensa (global)

Anticancer ALK inhibitor (2nd generation)

Chemistry

Molecular Formula	C30H34N4O2
PubChem	CID: 49806720 Open in PubChem

Structure

Half-life	32.5 hours
Tmax	4 h
Bioavailability	37 % (approx)
Protein Binding	99 %
Volume of Distribution	475 L/kg (approx)
Clearance Route	hepatic
Active Metabolites	yes
Notes	Major active metabolite M4; avoid with strong CYP3A inhibitors/inducers.

Severity: Moderate

Adverse Effects:
Constipation, myalgia, elevated CPK, hepatotoxicity

Contraindications:
Severe hepatic impairment

Precautions:
Monitor LFT, CPK periodically; photosensitivity counseling

Alectinib half-life ~32.5 hours → approx 1.35 days