Cycloserine
Brand: Seromycin (global) / Cyslin (IN)
Antibiotic
Anti-TB (D-alanine analog)
Pharmacokinetics
| Half-life | 10 hours |
| Tmax | 4 h |
| Bioavailability | 70 % (approx) |
| Protein Binding | 50 % |
| Volume of Distribution | 0.6 L/kg (approx) |
| Clearance Route | renal |
| Active Metabolites | no |
| Notes | Supplement Vitamin B6 to reduce neurotoxicity risk; monitor mental state regularly. |
⚠️ Safety & Warnings
Severity: Life-threatening
Adverse Effects:
Depression, psychosis, suicidal ideation, seizures
Contraindications:
Epilepsy, severe psychiatric illness
Precautions:
Always give Pyridoxine 50-100 mg/day; avoid alcohol; monitor mental status