Isoniazid
Brand: INH (global) / Isonex (IN/BD)
Antibiotic
Anti-TB (Hydrazide)
Pharmacokinetics
| Half-life | 3 hours |
| Tmax | 1 h |
| Bioavailability | 100 % (approx) |
| Protein Binding | 10 % |
| Volume of Distribution | 0.6 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | NAT2 slow acetylators higher hepatotoxicity risk; supplement pyridoxine (B6) mandatory. |
⚠️ Safety & Warnings
Severity: Severe
Adverse Effects:
Peripheral neuropathy, hepatotoxicity
Contraindications:
Severe liver disease
Precautions:
Always give Pyridoxine 10-25 mg/day; monitor LFTs; avoid alcohol