Ofloxacin
Brand: Tarivid (US/EU) / Oflin (IN) / Oflax (BD)
Antibiotic
Fluoroquinolone
Pharmacokinetics
| Half-life | 6 hours |
| Tmax | 1.5 h |
| Bioavailability | 95 % (approx) |
| Protein Binding | 25 % |
| Volume of Distribution | 1.5 L/kg (approx) |
| Clearance Route | renal |
| Active Metabolites | no |
| Notes | Dose commonly 200–400 mg bid; adjust in renal impairment. |
⚠️ Safety & Warnings
Severity: Severe
Adverse Effects:
Tendinopathy, dysglycemia, CNS effects
Contraindications:
Children, pregnancy (relative), previous FQ tendon rupture
Precautions:
Avoid co-prescription with steroids; caution elderly & diabetics