Cefuroxime
Brand: Zinacef (IV) / Ceftin (US/EU oral) / Cefurox (IN/BD)
Antibiotic
Cephalosporin 2nd generation
Pharmacokinetics
| Half-life | 1.5 hours |
| Tmax | 1 h |
| Bioavailability | 50 % (approx) |
| Protein Binding | 33 % |
| Volume of Distribution | 0.2 L/kg (approx) |
| Clearance Route | renal |
| Active Metabolites | no |
| Notes | Oral bioavailability lower vs IV; dosing varies by formulation and infection severity. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
GI upset, diarrhea, rash
Contraindications:
Immediate penicillin anaphylaxis
Precautions:
Cross-sensitivity with penicillin low but still evaluate allergy history