Cloxacillin
Brand: Orbenin (EU) / Cloxacil (IN/BD)
Antibiotic
Anti-staphylococcal penicillin
Pharmacokinetics
| Half-life | 0.8 hours |
| Tmax | 1 h |
| Bioavailability | 50 % (approx) |
| Protein Binding | 95 % |
| Volume of Distribution | 0.2 L/kg (approx) |
| Clearance Route | mixed |
| Active Metabolites | no |
| Notes | Best absorbed on empty stomach; avoid with food. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
GI upset, rash, cholestatic hepatitis (rare but well-known)
Contraindications:
Penicillin allergy
Precautions:
Monitor LFTs in prolonged therapy; watch for cholestasis