Cefixime
Brand: Suprax (US/EU) / Taxim-O (IN) / Cef-3 (BD)
Antibiotic
Cephalosporin 3rd generation (oral)
Pharmacokinetics
| Half-life | 3.5 hours |
| Tmax | 4 h |
| Bioavailability | 40 % (approx) |
| Protein Binding | 65 % |
| Volume of Distribution | 0.2 L/kg (approx) |
| Clearance Route | renal |
| Active Metabolites | no |
| Notes | Common dose 200 mg bid or 400 mg od. Long half-life supports once daily. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Diarrhea, dyspepsia, mild hepatic enzyme rise
Contraindications:
Immediate penicillin anaphylaxis
Precautions:
Monitor for diarrhea; consider C. difficile risk in broad use