Indomethacin
Brand: Indocap, Indomet (IN/BD), Indocin (global)
NSAID
Indole acetic acid derivative
Pharmacokinetics
| Half-life | 4.5 hours |
| Clearance Route | hepatic |
| Active Metabolites | none |
| Notes | Highly protein bound; CNS and GI adverse effects more common than many NSAIDs. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Severe gastric irritation, headache, dizziness, CNS effects, renal impairment, edema, hypertension
Contraindications:
Peptic ulcer disease, severe renal/hepatic impairment, perioperative CABG pain
Precautions:
Use cautiously in elderly, avoid in uncontrolled hypertension, monitor renal function