Atropine
Brand: Atropine Sulfate (global)
Emergency
Anticholinergic (muscarinic antagonist)
Pharmacokinetics
| Half-life | 2.5 hours |
| Tmax | 1 h |
| Bioavailability | 60 % (approx) |
| Protein Binding | 44 % |
| Volume of Distribution | 3 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Fast onset IV; dose titrated to heart rate response in bradycardia. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Dry mouth, blurred vision, urinary retention, tachycardia
Contraindications:
Narrow angle glaucoma
Precautions:
Monitor HR and blood pressure; avoid in obstructive uropathy