Dopamine
Brand: Dopamine (global)
Emergency
Catecholamine inotrope/vasopressor
Pharmacokinetics
| Half-life | 0.0333 hours |
| Tmax | 0.05 h |
| Bioavailability | 100 % (approx) |
| Protein Binding | 0 % |
| Volume of Distribution | 0.2 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Short t½; continuous IV with titration. Limited role; risk of tachyarrhythmia; avoid in pure septic shock. |
⚠️ Safety & Warnings
Severity: Severe
Adverse Effects:
Tachyarrhythmias, myocardial ischemia; extravasation injury
Contraindications:
Tachyarrhythmias
Precautions:
Monitor ECG, BP; central line preferred; manage extravasation with phentolamine