Clonazepam
Brand: Klonopin (US/EU) / Lonazep (IN) / Clonapam (BD)
Anxiolytic
Benzodiazepine anxiolytic (GABA-A positive allosteric modulator)
Pharmacokinetics
| Half-life | 34 hours |
| Tmax | 2 h |
| Bioavailability | 90 % (approx) |
| Protein Binding | 85 % |
| Volume of Distribution | 3 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | High potency; avoid abrupt withdrawal due to seizure risk. |
⚠️ Safety & Warnings
Severity: Severe
Adverse Effects:
Sedation, confusion, impaired coordination, dependence, withdrawal seizures
Contraindications:
Severe respiratory insufficiency, hepatic impairment
Precautions:
Avoid alcohol and opioids; taper very slowly when discontinuing.