Alprazolam

Brand: Xanax (US/EU) / Restyl (IN) / Alzolam (BD)

Anxiolytic Benzodiazepine anxiolytic (GABA-A positive allosteric modulator)

Chemistry

Molecular Formula	C17H13ClN4
PubChem	CID: 2118 Open in PubChem

Structure

Half-life	12 hours
Tmax	1.5 h
Bioavailability	80 % (approx)
Protein Binding	80 %
Volume of Distribution	1 L/kg (approx)
Clearance Route	hepatic
Active Metabolites	yes
Notes	Short half-life produces interdose withdrawal; CYP3A4 metabolism; avoid with strong inhibitors.

Severity: Severe

Adverse Effects:
Sedation, impaired judgment, memory impairment, dependency, withdrawal seizures

Contraindications:
Acute narrow-angle glaucoma, severe respiratory insufficiency

Precautions:
Avoid chronic daily use; taper slowly; avoid with alcohol and opioids.